Is Tobacco Use Associated with Neurocognitive Dysfunction in Individuals with HIV?

Is Tobacco Use Associated with Neurocognitive Dysfunction in Individuals with HIV?

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Introduction: The prevalence of HIV-associated neurocognitive disorders continues to ice blue graphic tee rise despite the widespread use of antiretroviral therapy.We aimed to define the risk of neurocognitive dysfunction among smokers relative to nonsmokers.Methods: We conducted a retrospective cohort study including HIV-infected adults ages 21 to 65 years.The Mental Alternation Test (MAT) was the primary outcome.The odds of cognitive impairment were compared using random-effects logistic regression to adjust for potential confounders.

Results: Of 3033, here 1486 (49%) were smokers.The odds ratio for the association between smoking and cognitive impairment was 1.12 (95% confidence interval: 0.85-1.49).

Nonsmokers had a higher median MAT score relative to smokers ( P =.01).Conclusion: There was no evidence that HIV-infected smokers had greater neurocognitive dysfunction relative to HIV-infected nonsmokers.While tobacco use remains an important health risk issue to address in the HIV population, it may not represent a risk factor for neurocognitive impairment.